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Rac1 (Ras-related C3 Botulinum toxin substrate 1, rho family, small GTP binding protein Rac1, Cell migration-inducing gene 5 protein, MGC111543, MIG5, p21-Rac1, Ras-like Protein TC25, Ras-related C3 botulinum toxin substrate 1, TC-25) (Agarose)

Cat no: R0400-02C

Rac1 (Ras-related C3 Botulinum toxin substrate 1, rho family, small GTP binding protein Rac1, Cell migration-inducing gene 5 protein, MGC111543, MIG5, p21-Rac1, Ras-like Protein TC25, Ras-related C3 botulinum toxin substrate 1, TC-25) (Agarose)

Rac is a member of the Rho family of small GTP-binding proteins, and plays roles in cytoskeletal actin organization as well as transformation. Rac is activated downstream of cdc42, or independently by Ras signaling, and in turn Rac stimulates Rho. Activation of Rac results in the formation of lamellipodia, whereas cdc42 stimulates filopodia formation, and Rho stimulates formation of actin stress fibers. Effectors of the Rac pathway include NADPH Oxidase and the SAPK1/JNK family of kinases. The latter pathway is activated by the PAK kinases, which are direct targets of Rac.\n\nApplications:\nSuitable for use in Immunoprecipitation and Immunoaffinity Chromatography methods. Other applications not tested.\n\nRecommended Dilutions:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

R0400-02C

Size

200ul

Applications

IP

Hosts

Mouse

Reactivities

Hum, Mouse, Rat

Conjugates

Agarose

Form

Supplied as a liquid, 0.05% sodium azide.

P Type

Mab

Purity

Ascites.

Isotype

IgG2b

Additional Info

Recognizes Rac1 with a strong preference. There is a slight Rac2 cross-reactivity. Species Crossreactivity: human, mouse, rat.

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