RGS19 (S151) (RGS19, GAIP, GNAI3IP, Regulator of G-protein signaling 19, G-alpha-interacting protein) (APC)

RGS19 enhances the intrinsic GTPase-activating protein activity of the Galphai3 protein, which stimulates autophagy by favoring the GDP-bound form of Galphai3. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole).\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:50-100\nImmunohistochemistry: 1:10-50\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

041007-APC

Size

200ul

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Allophycocyanin (APC).

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Baehrecke EH. Nat Rev Mol Cell Biol. 6(6):505-10. (2005) \nLum JJ, et al. Nat Rev Mol Cell Biol. 6(6):439-48. (2005) \nGreenberg JT. Dev Cell. 8(6):799-801. (2005) \nLevine B. Cell. 120(2):159-62. (2005) \nShintani T and Klionsky DJ. Science. 306(5698):990-5. (2004)\nde Vries L., et al. PNAS 93:15203-15208(1996) \nde Alba E., et al. J. Mol. Biol. 291:927-939(1999) \nWang J., et al. J. Biol. Chem. 273:26014-26025(1998) \nOgier-Denis E., et al. J. Biol. Chem. 275:39090-39095(2000)

Additional Info

Human, mouse

Alternative Names

RGS19, GAIP, GNAI3IP, Regulator of G-protein signaling 19, G-alpha-interacting protein