Supplier:
Cayman Chemical CompanyCat no: 160785
RICK Polyclonal Antibody
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SPECIFICATIONS
Catalog Number
160785
Applications
WB
Hosts
Rabbit
Form
1 ea
P Type
Antibodies|Intracellular Signaling
Weight
0
Antigen
human RICK amino acids 11-30 (PTIPYHKLADLRYLSRGASG){7167}
Storage Temp
-20
Shipping Temp
-20
Additional Info
Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. The DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase that regulates apoptosis was identified and designated RICK for RIP-like interacting CLARP kinase. RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. The RICK kinase domain has high sequence homology to that of RIP. Overexpression of RICK promotes the activation of caspase-8 and Fas-induced apoptosis. RICK represents a novel kinase that regulates Fas-induced apoptosis. The mRNA for RICK is expressed in multiple human tissues. RICK interacts with several Nod and T-cell receptor proteins and thereby confers signal transduction for innate and adaptive immune system responses.
Applications
ELISA, IF, IP, WB
Hosts
Rabbit
Applications
ELISA, IP, WB
Hosts
Rabbit
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