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ROR(gamma) Polyclonal Antibody

Cat no: 11003

ROR(gamma) Polyclonal Antibody

Antigen: a peptide within the region of amino acids 1-50 of human ROR(gamma) . Host: rabbit . Cross Reactivity: (+) chimpanzee and human ROR(gamma); predicted to react with bovine, canine, mouse, and rat ROR(gamma) . Application(s): IHC and WB

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SPECIFICATIONS

Catalog Number

11003

Applications

IHC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Nuclear Receptors|Intracellular Signaling

Weight

0

Antigen

A peptide within the region of amino acids 1-50 of human ROR(gamma)

Isotype

rabbit Ig

Storage Temp

-20

Shipping Temp

-20

Additional Info

ROR(gamma) is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. The specific functions of this protein are not known. However, reports suggest that this protein is a ligand activated transcription factor and may be essential for lymphoid organogenesis (lymph nodes and Peyer's patches) and may play an important regulatory role in controlling apoptosis during thymopoiesis. ROR(gamma) inhibits the expression of Fas ligand and IL2 and directs the differentiation program of proinflammatory IL-17+ T helper cells. ROR-(gamma) shares 50 to 51% sequence identity with ROR(alpha) and ROR(beta) and is 88% identical to mouse ROR(gamma). It is highly expressed in skeletal muscle and at lower levels in various other tissues.

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