RSK1 (Ribosomal S6 Kinase 1, RSK-1, 90kD Ribosomal Protein S6 Kinase 1, p90-RSK 1, p90RSK1, p90S6K, MAP Kinase-activated Protein Kinase 1a, MAPK-activated Protein Kinase 1a, MAPKAP Kinase 1a, MAPKAPK1A, MAPKAPK-1a, Ribosomal Protein S6 Kinase alpha-1, RPS

The p90 Ribosomal S6 kinases (RSKs) comprise a family of unique protein serine/threonine kinases that lie downstream of the mitogen activated protein kinases, predominantely ERK. Unlike other kinases however, the RSK family (RSK1, RSK2, RSK3 and RSK4) possess two kinase domains. Activation of ERK results in the phosphorylation and subsequent activation of RSKs. In turn, RSKs translocate to the nucleus where they phosphorylate a diverse range of nuclear substrates, many of which include transcription factors like c-Fos, estrogen receptor, NFkappaB/IkappaBalpha, cAMP-response element-binding protein (CREB) and CREB-binding protein. Consequently, the RSK family plays critical roles in mediating a number of biological responses including cell cycle regulation and protein synthesis, amongst others. (1

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SPECIFICATIONS

Catalog Number

R9399-04A

Size

100ug

Applications

ELISA, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Bov

Form

Supplied as a liquid in PBS. No stabilizing proteins added. No preservative added.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Frodin, M. and Gammeltoft, S. (1999) Mol. Cell. Endocrinol. 151: 65-77. \n2. Merienne, K., Jacquot, S., Trivier, E., Pannetier, S., Rossi, A., Scott, C., Schinzel, A., Castellan, C., Kress, W. and Hanauer, A. (1998) J. Med. Genet. 35: 890-894. \n3. De Cesare, D., Jacquot, S., Hanauer, A. and Sassone-Corsi, P. (1998) Proc. Natl. Acad. Sci. U.S.A. 95: 12202-12207. \n4. Joel, P. B., Smith, J., Sturgill, T. W., Fisher, T. L., Blenis, J. and Lannigan, D. A. (1998) Mol. Cell. Biol. 18: 1978-1984.

Additional Info

This antibody detects an ~90kD protein, corresponding to the apparent molecular mass of p90 RSK1. Species Crossreactivity: Human, mouse, rat and bovine.

Alternative Names

Ribosomal Protein S6 Kinase 90kDa Polypeptide 1, EC=2.7.11.1, HU-1