S1P1 Polyclonal Antibody

Antigen: human S1P1 amino acids 241-253 . Host: rabbit . Cross Reactivity: (+) human, mouse, porcine, and rat S1P1 . Application(s): ICC, IHC (formalin-fixed paraffin-embedded tissue), and WB . S1P exerts its activity by binding to five distinct GPCRs, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P1 primarily mediates S1P-induced cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. Expression of S1P1 is abundant in embryological vasculature and is ubiquitously expressed in adult cells suggesting diverse physiological functions of this receptor.

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SPECIFICATIONS

Catalog Number

10005228

Applications

ICC, IHC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Ceramides/Sphingolipids

Weight

0

Antigen

human S1P1 amino acids 241-253 (ISKASRSSEKSLA)

Storage Temp

-20

Shipping Temp

-20

Additional Info

Sphingosine-1-phosphate (S1P) exerts its activity by binding to five distinct G-protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P1 primarily couples with pertussis toxin-sensitive Gi/o proteins to mediate S1P-induced cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. Expression of S1P1 is abundant in embryological vasculature and is ubiquitously expressed in adult cells suggesting diverse physiological functions of this receptor. The human and mouse S1P1 receptors have 382 amino acids with an estimated molecular weight of 43 kDa. Glycosylation at the N-terminal extracellular domain may cause the protein to migrate at a higher position in SDS-PAGE. Cayman's S1P1 polyclonal antibody detects the receptor at 47 kDa by western blot analysis. The antibody can also be used for immunocytochemistry and immunohistochemistry to study expression patterns of this protein.