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S1P2 Polyclonal Antibody

Cat no: 13488

S1P2 Polyclonal Antibody

Antigen: synthetic peptide from human S1P2 amino acids 325-343 . Host: rabbit . Cross Reactivity: (+) human, monkey, mouse, and rat S1P2 . Application(s): WB . S1P2 acts as a receptor for the bioactive lipid S1P and participates in S1P-induced cell proliferation, survival, and transcriptional activation.

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SPECIFICATIONS

Catalog Number

13488

Applications

WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Ceramides/Sphingolipids

Weight

0

Antigen

synthetic peptide from human S1P2 amino acids 325-343

Storage Temp

-20

Shipping Temp

-20

Additional Info

S1P2 is a membrane protein belonging to the EDG family of extracellular G protein-coupled receptors. It acts as a receptor for the bioactive lipid sphingosine 1-phosphate (S1P) and participates in S1P-induced cell proliferation, survival, and transcriptional activation. It shares 92% amino acid identity with rat H218 and approximately 44% identity with the human S1P receptors EDG-1 and EDG-3. Though the role of S1P2 in vascular permeability is not clear, reports suggest that it regulates PTEN by a Rho GTPase-dependent pathway to inhibit cell migration. S1P2 also plays an important role in normal vascularization and hypoxia-triggered pathological angiogenesis of the mouse retina. The gene for human S1P2 protein is localized on chromosomal region 19p13.2. The protein is usually expressed in human brain and heart.

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