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Products S1P2 Polyclonal Antibody
| Catalogue number: | 13488 |
| Hosts: | Rabbit |
| Applications: | Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | synthetic peptide from human S1P2 amino acids 325-343 |
| P type: | Antibodies|Ceramides/Sphingolipids |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | S1P2 is a membrane protein belonging to the EDG family of extracellular G protein-coupled receptors. It acts as a receptor for the bioactive lipid sphingosine 1-phosphate (S1P) and participates in S1P-induced cell proliferation, survival, and transcriptional activation. It shares 92% amino acid identity with rat H218 and approximately 44% identity with the human S1P receptors EDG-1 and EDG-3. Though the role of S1P2 in vascular permeability is not clear, reports suggest that it regulates PTEN by a Rho GTPase-dependent pathway to inhibit cell migration. S1P2 also plays an important role in normal vascularization and hypoxia-triggered pathological angiogenesis of the mouse retina. The gene for human S1P2 protein is localized on chromosomal region 19p13.2. The protein is usually expressed in human brain and heart. |
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