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Products S1P3 Polyclonal Antibody
| Catalogue number: | 10006373 |
| Hosts: | Rabbit |
| Applications: | Immunocytochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human S1P3 amino acids 12-25 (VRGNETLREHYQYV) |
| P type: | Antibodies|Ceramides/Sphingolipids |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Sphingosine-1-phosphate (S1P) exerts its activity by binding to five distinct G-protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P3 couples to Gi/o-ERK, Gq-PLC, and G12/13-Rho axes to mediate S1P-induced cell proliferation, survival, migration, and related signaling events. S1P3 is widely expressed in various tissues, suggesting diverse physiological functions of this receptor. The human and mouse S1P3 have 378 amino acids with an estimated molecular weight of 42 kDa. Glycosylation at the N-terminal extracellular domain may cause the protein to migrate at different positions in SDS-PAGE. Cayman's S1P3 polyclonal antibody detects the receptor at 47 kDa using samples from human cerebral cortex. Liver and heart tissues display 2-3 bands between 40-50 kDa, possibly due to different degree of glycosylation. |
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