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Products S1P4 Polyclonal Antibody
| Catalogue number: | 13489 |
| Hosts: | Rabbit |
| Applications: | Immunocytochemistry, Immunofluorescence, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | synthetic peptide from human S1P4 within the region of amino acids 1-50 |
| P type: | Antibodies|Ceramides/Sphingolipids |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | EDG-6 is a member of the endothelial differentiation gene (EDG) G protein-coupled receptor family and is a receptor for sphingosine 1-phosphate (S1P). Binding of S1P to EDG-6 activates Erk, leading to the activation of the transcription factor Elk1 and thus the mitogen-activated protein kinase (MAPK) signal transduction pathway. The protein is specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Human EDG-6 gene is intronless and is mapped to chromosome 19p13.3 at the D19S120 marker. |
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