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Sclerostin, Human, Control Peptide

Cat no: S0501-05A

Sclerostin, Human, Control Peptide

The gene noggin encodes a member of one of at least four distinct gene families encoding secreted polypeptides that bind tomembers of the transforming growth factor-beta superfamily, suchas BMP, and inhibit the function of these signaling proteinsby preventing their interaction with receptors on the cell surface. Other antagonists with related functions includeChordin, Follistatin, Sclerostin and members of the DAN family. These BMP antagonists are assumed to be diffusibleand therefore potentially important in the establishment of BMPactivity gradients in vivo Although structurally distinct, members of these gene familieshave in some cases similar ligand specificity and overlappingpatterns of expression, and in the case of Chordin and Nogginthese proteins apparently are capable of at least partial compensationfor each other. In addition to these multiple secreted BMP antagonists, there are other secreted proteins whose primaryfunction is to overcome this antagonism. Thus, thereis a highly complex system to regulate the bioavailability andconsequently the activities of BMPs in the extracellularspace.\nBMPs are important regulators of key events in the processes of bone formation during embryogenesis, postnatal growth, remodeling and regeneration of the skeleton. The BMPs function by binding to a receptor complex that is found on all normal cells and is composed of type-I and

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SPECIFICATIONS

Catalog Number

S0501-05A

Size

50ug

Applications

ELISA

Form

Supplied as a liquid in PBS, pH 7.2.

Purity

Purified

References

Balemans, W. et al (2001) Genet. 10: 537-543; Brunkow, M. E et al (2001) Am. J. Hum. Genet. 68: 577-589; Tacconi, P. et al (1998) Clin. Genet. 53: 497-501.

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