SEPT2 (Septin 2, DIFF6, KIAA0158, NEDD5, Pnutl3, hNedd5, neural precursor cell expressed, developmentally down-regulated 5)

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes a protein associated with the tau-based paired helical filament core, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. SEPT2, otherwise known as septin-2, is a cytoskeletal GTPase and member of the septin family, essential for the formation of filaments, in conjunction with SEPT6 and SEPT7. SEPT2 plays an important role during mitosis progression/cytokinesis, in the correct organization of the actin cytoskeleton, and maintains polyGlu microtubule tracks, thereby facilitating epithelial cell vesicle transport.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nPeptide ELISA: 1:32,000. \nWestern Blot: 1-3ug/ml. A band is detected at 40kD band observed in Human, Mouse and Rat Testis lysates (calculated MW of 41.5kD according to NP_001008491.1). Optimal dilutions to be determined by the researcher.\n\nStorage and Stability: \nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can \n\nPeptide Blocking:\nCorresponding peptide is available for Peptide Blocking studies. See S0950-11-P. Antibody

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SPECIFICATIONS

Catalog Number

S0950-11

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by affinity chromatography.

References

Kremer BE, Adang LA, Macara IG. Septins regulate actin organization and cell-cycle arrest through nuclear\naccumulation of NCK mediated by SOCS7. Cell. 2007 Sep 7;130(5):837-50.

Additional Info

Recognizes human SEPT2. Species sequence homology: mouse, rat and bovine.

Alternative Names

SEPT2; septin 2; DIFF6; KIAA0158; NEDD5; Pnutl3; hNedd5; neural precursor cell expressed, developmentally down-regulated 5