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Serotonin Transporter (SERT, hSERT, 5-Hydroxytryptamine Transporter, 5HT Transporter, 5HTT, 5-HTT, HTT, OCD1, Na+/Cl-dependent Serotonin Transporter, Sodium-dependent Serotonin Transporter, Solute Carrier Family 6 Member 4, SLC6A4)

Cat no: S1001-25C

Serotonin Transporter (SERT, hSERT, 5-Hydroxytryptamine Transporter, 5HT Transporter, 5HTT, 5-HTT, HTT, OCD1, Na+/Cl-dependent Serotonin Transporter, Sodium-dependent Serotonin Transporter, Solute Carrier Family 6 Member 4, SLC6A4)

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nPeptide ELISA: 1:32,000 \nWestern Blot: 1-3ug/ml. Bands of ~70-75kD were observed in human duodenum lysates.\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S1001-25C

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in TBS, pH 7.3, 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Voeller KK. Attention-deficit hyperactivity disorder (ADHD). J Child Neurol. (2004) 19:798-814.

Additional Info

Recognizes the human Serotonin Transporter.

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