Home  >  Products  >  Sex Hormone-Binding Globulin (SHBG, Sex Steroid-binding Protein, SBP, Testis-specific Androgen-binding Protein, BP, Testosterone-estradiol-binding Globulin, TeBG, Testosterone-estrogen-binding Globulin)
Sex Hormone-Binding Globulin (SHBG, Sex Steroid-binding Protein, SBP, Testis-specific Androgen-binding Protein, BP, Testosterone-estradiol-binding Globulin, TeBG, Testosterone-estrogen-binding Globulin)

Sex Hormone-Binding Globulin (SHBG, Sex Steroid-binding Protein, SBP, Testis-specific Androgen-binding Protein, BP, Testosterone-estradiol-binding Globulin, TeBG, Testosterone-estrogen-binding Globulin)

Cat no: S1012-52H

Supplier: United States Biological
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SHBG is a protein of mol wt 90kD (402aa) containing two subunits. SHBG transports the sex steroids testosterone, DHT and estradiol in the blood. Serum levels are increased during pregnancy, in women taking estrogens, and in men over the age of 50. Levels are reduced after menopause and in response to treatment with androgens or corticosteroids. Diagnostic uses include polycystic ovary disease and tests for liver and thyroid function Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: ELISA: 1:10,000-1:100,000 Western Blot: 1:1000-1:5000 using chemiluminescence Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S1012-52H
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a lyophillized powder from PBS, 0.1% BSA. Reconstitute in 100ul sterile PBS.
P type: Mab
Isotype: IgG2a
Purity: Purified by immunoaffinity chromatography.
References: 1. Hammond GI (1987) FEBS Lett. 215, 100- 104. 2. Hammond GI (1986) J. Steroid Biochem. 24, 815-824. 3. Powers SG (1992) J. Clin. Endocrinol. Metab. 75 (4), 1066-1070. 4. Grishkovskaya,I (2002) J. Biol. Chem. 277 (35), 32086-32093.
Additional info: Recognizes human Sex Hormone-Binding Globulin.

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