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SH3GLB2, Recombinant, Human, aa1-395, His-Tag (Endophilin-B2, PP6569, PP9455)

Cat no: 138740

SH3GLB2, Recombinant, Human, aa1-395, His-Tag (Endophilin-B2, PP6569, PP9455)

Endophilin-B2, also known as SH3GLB2, is a member of the endophilin B subgroup. The endophilins comprise a family of proteins that associate with amphiphysin, synaptojanin and dynamin and are implicated in presynaptic vesicle trafficking at nerve terminals. The expression patterns of the endophilins are consistent with their cellular functions at the neuronal synapse. SH3GLB2 is ubiquitously expressed but shows highest levels in brain, adult lung, ovary, and spinal cord. A decreased level of SH3GLB2 is found in Down syndrome and may reflect brain dysgenesis. \n\nSource:\nRecombinant protein corresponding to aa1-395 from human SH3GLB2 at N-terminal, fused to His-tag expressed in E.coli. \n\nMolecular Weight: \n~46.4kD (418aa)\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGSMDFNMKK LASDAGIFFT RAVQFTEEKF GQAEKTELDA HFENLLARAD STKNWTEKIL RQTEVLLQPN PSARVEEFLY EKLDRKVPSR VTNGELLAQY MADAASELGP TTPYGKTLIK VAEAEKQLGA AERDFIHTAS ISFLTPLRNF LEGDWKTISK ERRLLQNRRL DLDACKARLK KAKAAEAKAT TVPDFQETRP RNYILSASAS ALWNDEVDKA EQELRVAQTE FDRQAEVTRL LLEGISSTHV NHLRCLHEFV KSQTTYYAQC YRHMLDLQKQ LGRFPGTFVG TTEPASPPLS STSPTTAAAT MPVVPSVASL APPGEASLCL EEVAPPASGT RKARVLYDYE AADSSELALL ADELITVYSL PGMDPDWLIG ERGNKKGKVP VTYLELLS\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

138740

Size

100ug

Form

Supplied as a liquid in 20mM tris-HCl buffer, pH 8.0, 0.15M sodium chloride, 1mM DTT, 30% glycerol.

Purity

~85% (SDS-PAGE)

References

1. Pierrat B., et al. (2001) Genomics. 71:222-234 2. Engidawork E., et al. (2003) Neuroscience. 122: 145-154.

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