Ski-like Protein (Ski-related Oncogene, Ski-related Protein, SNO, SKIL)

SnoN, an 80kD protein, is a member of ski family of nuclear proto-oncogenes involved in regulation of cellular transformation and differentiation. Primarily expressed in two isoforms, SnoN is localized in cytoplasm in normal tissues and non-tumorigenic primary epithelial cells. In cancer tissues or cells, SnoN is exclusively localized in the nucleus. It plays a vital role in inhibition of cell cycle arrest induced by TGF-

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SPECIFICATIONS

Catalog Number

S1013-89Z2

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by Protein G affinity Chromatography.

Isotype

IgG

References

1. Poser,I., Rothhammer,T., Dooley,S., Weiskirchen,R. and Bosserhoff,A.K. Characterization of Sno expression in malignant melanoma Int. J. Oncol. 26 (5), 1411-1417 (2005). 2. Sarker,K.P., Wilson,S.M. and Bonni,S. SnoN is a cell type-specific mediator of transforming growth factor-beta responses. J. Biol. Chem. 280 (13), 13037-13046 (2005). 3. He,J., Tegen,S.B., Krawitz,A.R., Martin,G.S. and Luo,K. The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins. J. Biol. Chem. 278 (33), 30540-30547 (2003).

Additional Info

Recognizes human Ski-Like Protein. Species Crossreactivity: mouse and rat. Species sequence homology: chimpanzee, chicken, orangutan.