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SLC7A11, ID (Cystine/Glutamate Transporter, Amino Acid Transport System xc-, Calcium Channel Blocker Resistance Protein CCBR1, Solute Carrier Family 7 Member 11, xCT)

Cat no: S5329-08K

SLC7A11, ID (Cystine/Glutamate Transporter, Amino Acid Transport System xc-, Calcium Channel Blocker Resistance Protein CCBR1, Solute Carrier Family 7 Member 11, xCT)

Mammalian amino acid transport systems consist of a large variety of transporters. The amino acid transporter, cystine/glutamic acid transporter xCT, for system xc has been proposed to be responsible for the cystine transport through the plasma membrane. System xc mediates an amino acid exchange and prefers cystine and glutamate as its substrates. The transporter designated as xCT requires 4F2 heavy chain (4F2hc:CD98) for its functional expression, and belongs to the family of amino acid transporters that associates with the type II membrane glycoproteins such as 4F2hc. In brain, it has been proposed that system xc is up-regulated in glial cells upon oxidative stress and plays an essential roles to protect neurons against oxidative stress. Recent studies have implicated xCT as a gateway that Kaposi's sarcoma Herpes virus (KSHV) uses to enter cells.\n\nApplications:\nSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.02-0.06ug/ml\nELISA: 1:128,000\nImmunohistochemistry (Formalin fixed paraffin embedded): 3.75ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S5329-08K

Size

50ug

Applications

ELISA, IHC, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Additional Info

Recognizes human SLC7A11. Species sequence homology: canine.

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