SLURP1, Secreted Ly-6/uPAR-related Protein 1

Secreted Ly-6/uPAR-related protein 1, SLURP1, is a 9kD secreted member of the Ly-6/uPAR protein superfamily. Human SLURP1 is synthesized as a 103aa precursor that contains a 21aa signal sequence and an 82aa mature chain. Like other members of the Ly-6/uPAR family, SLURP1 contains a Ly-6/uPAR domain (aa24-73)and ten cysteine residues that make up five disulfide bonds. Unlike other family members, however, SLURP1 does not contain a GPI anchor. Mature human SLURP1 shares 67% and 68% aa identity with mouse and rat SLURP1, respectively. The protein forms a homodimer and is expressed in skin, eye, whole lung, trachea, esophagus, and stomach. In humans, SLURP1 is involved in maintaining the integrity of the kerotinocyte layers of the skin and has demonstrated antitumor activity.\n\nApplications: \nSuitable for use in Direct ELISA and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nDirect ELISA: 0.5-1ug/ml. The detection limit is ~5ng/lane.\nImmunohistochemistry: 25ug/ml\nOptimal dilutions to be determined by the researcher.\n\nHybridoma: \nMyeloma cells with B cells from Balb/c mice. \n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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