SMAD3 Polyclonal Antibody

Antigen: portion of amino acids 100-150 of human SMAD3 . Host: rabbit . Cross Reactivity: (+) Bovine, canine, human, mouse, porcine, rat, and rhesus monkey SMAD3; predicted to react with chicken, Xenopus, and zebrafish SMAD3 . Application(s): IHC and WB . SMAD3 is a receptor-regulated SMAD (R-SMAD) that functions downstream of TGF-(beta) and activin receptors and mediates their signaling. It is recruited by SARA (SMAD anchor for receptor activation) to the receptor kinase for phosphorylation. Upon phosphorylation it plays role in cell proliferation, differentiation, apoptosis and formation of ECM.

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SPECIFICATIONS

Catalog Number

10832

Applications

IHC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Intracellular Signaling

Weight

0

Antigen

portion of amino acids 100-150 of human SMAD3

Storage Temp

-20

Shipping Temp

-20

Additional Info

SMAD3, a member of the SMAD family of proteins, is involved in the TGF-(beta) signaling cascade. A human homolog of Drosophila Mad protein, SMAD3 consists of an N-terminal DNA-binding MH1 domain, a linker region and a C-terminal MH2 domain. It is a receptor-regulated SMAD (R-SMAD) that functions downstream of TGF-(beta) and activin receptors and mediates their signaling. It is recruited by SARA (SMAD anchor for receptor activation) to the receptor kinase for phosphorylation. Upon phosphorylation, SMAD3 dissociates from SARA, forms a complex with SMAD4 and transmigrates into the nucleus where it complexes with other cofactors and acts as a transcription factor. It has an indispensable role in cell proliferation, differentiation, apoptosis and formation of ECM. Loss of SMAD3 results in Childhood T-cell leukemia.