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Products SOAT-1/ACAT-1 Polyclonal Antibody
| Catalogue number: | 100028 |
| Hosts: | Rabbit |
| Applications: | Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human SOAT-1/ACAT-1 amino acids 6-23 (KMSLRNRLSKSRENPEED) |
| P type: | Antibodies |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Sterol O-acyltransferase 1 (SOAT-1), also known as acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) catalyzes the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A. SOAT-1/ACAT-1 may be involved in maintaining appropriate membrane free cholesterol levels and in lipid droplet formation, and thus play a role in the development of atherosclerosis. SOAT-1/ACAT-1 is ubiquitously expressed, with highest levels observed in sebaceous glands, steroidogenic tissues, and macrophages. This intracellular enzyme is located at the endoplasmic reticulum and has as many as eight transmembrane domains. Human SOAT-1/ACAT-1 has 550 amino acids with an estimated molecular weight of 65 kDa. Cayman's affinity-purified antibody recognizes a 50 kDa band in most cultured cell lines as reported in the literature. In addition, the antibody reacts with a native form of ACAT-1 at about 65 kDa in liver tissues. |
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