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SOAT-1/ACAT-1 Polyclonal Antibody

Cat no: 100028

SOAT-1/ACAT-1 Polyclonal Antibody

Antigen: human SOAT-1/ACAT-1 amino acids 6-23 . Host: rabbit . Cross Reactivity: (+) human, mouse, porcine, and rat SOAT-1/ACAT-1 . Application(s): WB . SOAT-1/ACAT-1 catalyzes the formation of cholesterol esters from cholesterol and long chain fatty acyl-CoA, and may play a role in the development of atherosclerosis.

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SPECIFICATIONS

Catalog Number

100028

Applications

WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

human SOAT-1/ACAT-1 amino acids 6-23 (KMSLRNRLSKSRENPEED)

Storage Temp

-20

Shipping Temp

-20

Additional Info

Sterol O-acyltransferase 1 (SOAT-1), also known as acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) catalyzes the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A. SOAT-1/ACAT-1 may be involved in maintaining appropriate membrane free cholesterol levels and in lipid droplet formation, and thus play a role in the development of atherosclerosis. SOAT-1/ACAT-1 is ubiquitously expressed, with highest levels observed in sebaceous glands, steroidogenic tissues, and macrophages. This intracellular enzyme is located at the endoplasmic reticulum and has as many as eight transmembrane domains. Human SOAT-1/ACAT-1 has 550 amino acids with an estimated molecular weight of 65 kDa. Cayman's affinity-purified antibody recognizes a 50 kDa band in most cultured cell lines as reported in the literature. In addition, the antibody reacts with a native form of ACAT-1 at about 65 kDa in liver tissues.

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