Home  >  Products  >  SOCS3 (Suppressor of Cytokine Signaling 3, SOCS-3, Cytokine-inducible SH2 Protein 3, CIS-3, SSI-3, CIS3, SSI3, STAT-induced STAT Inhibitor 3)
SOCS3 (Suppressor of Cytokine Signaling 3, SOCS-3, Cytokine-inducible SH2 Protein 3, CIS-3, SSI-3, CIS3, SSI3, STAT-induced STAT Inhibitor 3)

SOCS3 (Suppressor of Cytokine Signaling 3, SOCS-3, Cytokine-inducible SH2 Protein 3, CIS-3, SSI-3, CIS3, SSI3, STAT-induced STAT Inhibitor 3)

Cat no: S1040-03R

Supplier: United States Biological
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This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. Applications: Suitable for use in Western Blot, ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:500 Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1040-03R
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein A affinity chromatography.
Additional info: Recognizes human SOCS3.

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