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Products Soluble Epoxide Hydrolase Cell-Based Assay Kit
| Catalogue number: | 600090 |
| Weight: | 0 |
| Form: | 480 Well |
| P type: | Assay Kits |
| Shipping temp: | -80 |
| Storage temp: | -80 |
| Additional info: | Mammalian soluble epoxide hydrolase (sEH) is a member of the (alpha)/(beta)-hydrolase fold family of enzymes that catalyze the hydrolysis of exogenous and endogenous epoxides to vicinal diols. sEH is a homodimer consisting of two domains. The C-terminal domain is responsible for the epoxide hydrolase activity while the N-terminal domain has a catalytic center with phosphatase activity. Endogenous substrates for sEH include epoxyeicosatrienoic acids (EETs) which exhibit vasodilatory and anti-inflammatory activity. Inhibition of sEH in animal models was shown to effectively treat hypertension and vascular inflammation as well as related syndromes. These studies demonstrate the value for targeting sEH for development of small molecule inhibitors as therapeutics. Cayman |
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