

Supplier:
Cayman Chemical CompanyCat no: 600090
Soluble Epoxide Hydrolase Cell-Based Assay Kit
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SPECIFICATIONS
Catalog Number
600090
Form
480 Well
P Type
Assay Kits
Weight
0
Storage Temp
-80
Shipping Temp
-80
Additional Info
Mammalian soluble epoxide hydrolase (sEH) is a member of the (alpha)/(beta)-hydrolase fold family of enzymes that catalyze the hydrolysis of exogenous and endogenous epoxides to vicinal diols. sEH is a homodimer consisting of two domains. The C-terminal domain is responsible for the epoxide hydrolase activity while the N-terminal domain has a catalytic center with phosphatase activity. Endogenous substrates for sEH include epoxyeicosatrienoic acids (EETs) which exhibit vasodilatory and anti-inflammatory activity. Inhibition of sEH in animal models was shown to effectively treat hypertension and vascular inflammation as well as related syndromes. These studies demonstrate the value for targeting sEH for development of small molecule inhibitors as therapeutics. Cayman
Applications
ELISA, IF, IP, WB
Hosts
Rabbit
Applications
ELISA, IP, WB
Hosts
Rabbit
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