Somatostatin Receptor Type 2 (SSTr2)

Somatostatin is a tetradecapeptide that is widely distributed in the body. It acts on multiple organs in the body and also functions as a neuropeptide affecting electrical activity of neurons. Somatostatin Receptor 2 (SSR2), along with SSR1, is expressed at the highest levels in the stomach and jejunum, cerebrum and kidney, respectively.\nSomatostatin acts to regulate numerous physiological processes by binding to and activating specific receptors in target tissues. Activation of these receptors by somatostatin, which is secreted by nerve and endocrine cells, regulates the secretion of insulin, glucagon and growth hormone, neuronal excitability in both the brain and the peripheral nervous system, and cell growth. Somatostatin receptors have been implicated in numerous diseases ranging from Alzheimer's to cancers of the gastrointestinal tract, breast, prostate, and pituitary. \nSomatostatin was originally isolated from the hypothalamus and characterized by its ability to inhibit release of growth hormone from the pituitary gland. It exists in two forms, somatostatin-14, composed of 14 amino acids and somatostatin-28, a prohormone composed of 28 residues.\n\nApplications: \nSuitable for use in ELISA, Immunohistochemistry, Immunofluorescence and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:100-1:1000 (ECL) (75-85kD band; may see smaller MW bands as well)\nImmunofluorescence 1:100-1:250\nImmunohistochemistry: Parrafin\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability: \nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.\n\nSubject to uses under US Patent No. 05/998,154

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SPECIFICATIONS

Catalog Number

S5331-46

Size

100ul

Applications

ELISA, IF, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as neat serum with 0.05% sodium azide.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Gu, Y.Z., and Schonbrunn, A. Molecular Endocrinology. 11: 527-537, 1997. 2. Reubi, J.C., et al., . American Journal of Pathology 153: 233-245, 1998.

Additional Info

Recognizes rat SSTr2. Species Crossreactivity: human and mouse