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Products Sphingomyelinase Inhibitor Screening Assay Kit
| Catalogue number: | 700330 |
| Weight: | 0 |
| Form: | 96 Well |
| P type: | Assay Kits |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Sphingomyelinase (SMase) is a hydrolase enzyme that is involved in sphingolipid metabolism. SMase is a member of the DNase I superfamily of enzymes and is responsible for the breakdown of sphingomyelin into phosphocholine and ceramide. The activation of SMase has been suggested as a major route for the production of ceramide in response to cellular stress. SMases are important in many physiological and pathophysiological processes, including: 1. lysosomal digestion of sphingomyelin, which is important for normal neuronal and vascular function; 2. ceramide-mediated signal transduction, leading to cytokine-induced apoptosis, cellular differentiation, and various immune and inflammatory responses; 3. lipoprotein aggregation within the vessel wall, which is a key event in atherogenesis; and 4. intracellular cholesterol trafficking and metabolism. Finding inhibitors to SMase (both acidic and neutral enzymes) could be beneficial in determining agents which reduce SMase activity and ceramide levels leading to attenuation of apoptosis and cellular proliferation, possible anti-depressant effects in depressive disorders, and beneficial clinical effects in acute or chronic neurodegenerative disorders, such as stroke and Alzheimer |
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