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Products Sphingosine Kinase 1 Polyclonal FITC Antibody
| Catalogue number: | 10012201 |
| Hosts: | Rabbit |
| Applications: | Flow Cytometry, Immunofluorescence, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human SPHK 1 amino acids 264-274 |
| P type: | Antibodies|Intracellular Signaling |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | The primary use of this antibody conjugate is for the detection of SPHK 1 in intact cells by direct immunolabeling methods such as flow cytometry or immunofluorescence microscopy. SPHK 1 is one of the enzymes involved in sphingolipid metabolism. SPHK 1 catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate. This reaction plays an important role in determining cell proliferation versus cell death. SPHK 1 is found in a wide variety of tissues and cell types including kidney, liver, spleen, heart, platelets, and human tumors. On a cellular level, it is found in the cytosolic and membrane fractions. Based on the amino acid sequence, this protein has a molecular weight of approximately 43 kDa. Some reported post translational modifications may explain the shift in band migration to 50 kDa. NOTE: Multiple isoforms of SPHK 1 are known and one is 470 amino acids. This likely explains the 50 kDa band observed. |
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