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sPLA2 (human Type V) Monoclonal Antibody (Clone MCL-3G1)

Cat no: 160510

sPLA2 (human Type V) Monoclonal Antibody (Clone MCL-3G1)

Antigen: purified human recombinant sPLA2 (type V), W79A mutant . Host: mouse . Cross-Reactivity: (+) human sPLA2 (type V); (-) human sPLA2 (type IIa) and cPLA2 . Application(s): ELISA, IHC (formalin-fixed paraffin-embedded tissue), and WB . Isotype: IgG1 . Clone designation: MCL-3G1

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SPECIFICATIONS

Catalog Number

160510

Applications

ELISA, IHC, WB

Hosts

Mouse

Form

100 microg

P Type

Antibodies|Enzymes|Phospholipase|Eicosanoids

Weight

0

Antigen

purified human recombinant sPLA2 (type V), W79A mutant

Isotype

IgG1

Storage Temp

-20

Shipping Temp

-20

Additional Info

Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids. PLA2 (type V) is a secretory PLA2 (sPLA2) of approximately 14 kDa and is one of the isoforms in the growing list of the PLA2 enzyme family. This enzyme, rather than the sPLA2 (type II), is responsible for arachidonic acid mobilization leading to prostaglandin production in macrophages and mast cells. Consistent with this role, sPLA2 (type V) is associated with the golgi apparatus, nuclear envelope, and plasma membrane in murine bone marrow-derived mast cells. sPLA2 (type V) has been cloned from a variety of species including human, mouse, and rat. The enzyme is expressed in heart, lung, placenta, and spleen, as well as P388D1 macrophages and mast cells.

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