SQSTM1 (Sequestosome-1, EBI3-associated Protein of 60 kDa, EBIAP, p60, ORCA, OSIL, Phosphotyrosine-independent Ligand for the Lck SH2 Domain of 62 kDa, Ubiquitin-binding Protein p62)

Size

100ug

Hosts

Mouse

Form

Supplied as a liquid in PBS, pH 7.2.

Purity

Purified by Protein A affinity chromatography.

References

1. Host Cell Autophagy Modulates Early Stages of Adenovirus Infections in Airway Epithelial Cells. Zeng X, Carlin CR.J Virol. 2012 Dec 12. 2. Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model. Gan L, Vargas MR, Johnson DA, Johnson JA.J Neurosci. 2012 Dec 5;32(49):17775-87. doi: 10.1523/JNEUROSCI.3049-12.2012. 3. Hyperactivation of the mammalian degenerin MDEG promotes caspase-8 activation and apoptosis. Pan JA, Fan Y, Gandhirajan RK, Madesh M, Zong WX.J Biol Chem. 2012 Dec 13. 4. Defective autophagy and mTORC1 signaling in myotubularin null mice. Fetalvero KM, Yu Y, Goetschkes M, Liang G, Valdez RA, Gould T, Triantafellow E, Bergling S, Loureiro J, Eash J, Lin V, Porter JA, Finan PM, Walsh K, Yang Y, Mao X, Murphy LO.Mol Cell Biol. 2012 Oct 29. [Epub ahead of print] 5. Recombinant protein rVP1 upregulates BECN1-independent autophagy, MAPK1/3 phosphorylation and MMP9 activity via WIPI1/WIPI2 to promote macrophage migration. Liao CC, Ho MY, Liang SM, Liang CMAutophagy. 2013 Jan;9(1):5-19. doi: 10.4161/auto.22379. Epub 2012 Oct 10. 6. (-)-Epigallocatechin-3-Gallate Induces Non-Apoptotic Cell Death in Human Cancer Cells via ROS-Mediated Lysosomal Membrane Permeabilization. Zhang Y, Yang ND, Zhou F, Shen T, Duan T, Zhou J, Shi Y, Zhu XQ, Shen HM.PLoS One. 2012;7(10):e46749. doi: 10.1371/journal.pone.0046749. Epub 2012 Oct 8. 7. West Nile Virus (WNV) Replication Is Independent of Autophagy in Mammalian Cells. Vandergaast R, Fredericksen BL.PLoS One. 2012;7(9):e45800. doi: 10.1371/journal.pone.0045800. Epub 2012 Sep 21. 8. Rotenone Inhibits Autophagic Flux Prior to Inducing Cell Death. Mader BJ, Pivtoraiko VN, Flippo HM, Klocke BJ, Roth KA, Mangieri LR, ShackaJJ.ACS Chem. Neurosci. DOI: 10.1021/cn300145z 9. Tissue Specific Induction of p62/Sqstm1 by Farnesoid X Receptor. Williams JA, Thomas AM, Li G, Kong B, Zhan L, Inaba Y, Xie W, Ding WX, Guo GL.PLoS One. 2012;7(8):e43961. Epub 2012 Aug 27. 10. Sorafenib has potent anti-tumor activity in multiple myeloma in vitro, ex vivo and in vivo, in the 5T33MM mouse model. Kharaziha P, De Raeve H, Fristedt C, Li Q, Gruber A, Johnsson P, Kokaraki G, Panzar M, Laane E, Osterborg A, Zhivotovsky B, Jernberg-Wiklund H, Grander D, Celsing F, Bjorkholm M, Vanderkerken K, Panaretakis T.Cancer Res. 2012 Sep 4. 11. Genetic Ablation of Nrf2/Antioxidant Response Pathway in Alexander Disease Mice Reduces Hippocampal Gliosis but Does Not Impact Survival. Hagemann TL, Jobe EM, Messing A.PLoS One. 2012;7(5):e37304. Epub 2012 May 31. 12. MAP1B Interaction with the FW Domain of the Autophagic Receptor Nbr1 Facilitates Its Association to the Microtubule Network. Marchbank K, Waters S, Roberts RG, Solomon E, Whitehouse CA.Int J Cell Biol. 2012;2012:208014. Epub 2012 May 10. 13. Liver-specific loss of atg5 causes persistent activation of nrf2 and protects against acetaminophen-induced liver injury. Ni HM, Boggess N, McGill MR, Lebofsky M, Borude P, Apte U, Jaeschke H, Ding WX.Toxicol Sci. 2012 Jun;127(2):438-50. Epub 2012 Apr 5. 14. Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice. Menon S, Yecies JL, Zhang HH, Howell JJ, Nicholatos J, Harputlugil E, Bronson RT, Kwiatkowski DJ, Manning BD.Sci Signal. 2012 Mar 27;5(217):ra24. 15. Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice. Ghazi-Noori S, Froud KE, Mizielinska S, Powell C, Smidak M, Fernandez de Marco M, O'Malley C, Farmer M, Parkinson N, Fisher EM, Asante EA, Brandner S, Collinge J, Isaacs AM.Brain. 2012 Mar;135(Pt 3):819-32. 16. A centronuclear myopathy-dynamin 2 mutation impairs autophagy in mice. Durieux AC, Vassilopoulos S, Laine J, Fraysse B, Brinas L, Prudhon B, Castells J, Freyssenet D, Bonne G, Guicheney P, Bitoun M.Traffic. 2012 Feb 28. doi: 10.1111/j.1600-0854.2012.01348.x. [Epub ahead of print] 17. Targeting of distinct signaling cascades and cancer-associated fibroblasts define the efficacy of Sorafenib against prostate cancer cells. Kharaziha P, Rodriguez P, Li Q, Rundqvist H, Bjorklund AC, Augsten M, Ullen A, Egevad L, Wiklund P, Nilsson S, Kroemer G, Grander D, Panaretakis T.Cell Death Dis. 2012 Jan 26;3:e262. doi: 10.1038/cddis.2012.1. 18. Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. Jaber N, Dou Z, Chen JS, Catanzaro J, Jiang YP, Ballou LM, Selinger E, Ouyang X, Lin RZ, Zhang J, Zong WX.Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2003-8. Epub 2012 Jan 23. 19. Cathepsin Cleavage of Sirtuin-1 in Endothelial Progenitor Cells Mediates Stress-Induced Premature Senescence. Chen J, Xavier S, Moskowitz-Kassai E, Chen R, Lu CY, Sanduski K, Spes A, Turk B, Goligorsky MS.Am J Pathol. 2012 Jan 9. [Epub ahead of print] 20. Autophagic degradation of tau in primary neurons and its enhancement by trehalose. Kruger U, Wang Y, Kumar S, Mandelkow EM.Neurobiol Aging. 2011 Dec 12. 21. Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Deng HX, Chen W, Hong ST, Boycott KM, Gorrie GH, Siddique N, Yang Y, Fecto F, Shi Y, Zhai H, Jiang H, Hirano M, Rampersaud E, Jansen GH, Donkervoort S, Bigio EH, Brooks BR, Ajroud K, Sufit RL, Haines JL, Mugnaini E, Pericak-Vance MA, Siddique T.Nature. 2011 Aug 21;477(7363):211-5. doi: 10.1038/nature10353. 22. Modulation of pediatric brain tumor autophagy and chemosensitivity. Levy JM, Thorburn A.J Neurooncol. 2011 Aug 13. [Epub ahead of print] 23. Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery. Kovacs JR, Li C, Yang Q, Li G, Garcia IG, Ju S, Roodman DG, Windle JJ, Zhang X, Lu B.Cell Death Differ. 2011 Jun 10. doi: 10.1038/cdd.2011.78. [Epub ahead of print] 24. Pancreatic cancers require autophagy for tumor growth. Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC.Genes Dev. 2011 Apr 1;25(7):717-29. Epub 2011 Mar 15. 25. Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity. Whitehouse CA, Waters S, Marchbank K, Horner A, McGowan NW, V Jovanovic J, Xavier GM, Kashima TG, Cobourne MT, Richards GO, Sharpe PT, Skerry TM, Grigoriadis AE, Solomon E.Proc Natl Acad Sci U S A. 2010 Jun 29. [Epub ahead of print] 26. 14-3-3Tau regulates Beclin 1 and is required for autophagy. Wang B, Ling S, Lin WC.PLoS One. 2010 Apr 29;5(4):e10409. 27. In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells. Lee HK, Mattei LM, Steinberg BE, Alberts P, Lee YH, Chervonsky A, Mizushima N, Grinstein S, Iwasaki A.Immunity. 2010 Feb 26;32(2):227-39. Epub 2010 Feb 18. 28. Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. Wu YT, Tan HL, Shui G, Bauvy C, Huang Q, Wenk MR, Ong CN, Codogno P, Shen HM.J Biol Chem. 2010 Apr 2;285(14):10850-61. Epub 2010 Feb 1. 29. Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling. Mardakheh FK, Yekezare M, Machesky LM, Heath JK.J Cell Biol. 2009 Oct 12. [Epub ahead of print] 30. Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2. Ferguson CJ, Lenk GM, Meisler MH.Hum Mol Genet. 2009 Dec 15;18(24):4868-78. Epub 2009 Sep 29. 31. Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism. Gal J, Strom AL, Kwinter DM, Kilty R, Zhang J, Shi P, Fu W, Wooten MW, Zhu H.J Neurochem. 2009 Nov;111(4):1062-73. Epub 2009 Sep 18. 32. Monitoring autophagic degradation of p62/SQSTM1. Bjorkoy G, Lamark T, Pankiv S, Overvatn A, Brech A, Johansen T.Methods Enzymol. 2009;452:181-97. 33. Loss of Autophagy Diminishes Pancreatic ?] Cell Mass and Function with Resultant Hyperglycemia. Jung HS, Chung KW, Won Kim J, Kim J, Komatsu M, Tanaka K, Nguyen YH, Kang TM, Yoon KH, Kim JW, Jeong YT, Han MS, Lee MK, Kim KW, Shin J, Lee MS.Cell Metab. 2008 Oct;8(4):318-24.

Alternative Names

A170, p60, p62, p62B, PDB3, ZIP3