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STAT6, phosphorylated (Thr645) (Signal Transducer And Activator of Transcription 6, IL-4 Stat)

STAT6, phosphorylated (Thr645) (Signal Transducer And Activator of Transcription 6, IL-4 Stat)

Cat no: S7972-42M

Supplier: United States Biological
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STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. STAT6 is rapidly tyrosine phosphorylated following stimulation of appropriate cell lines with IL-3, IL-4, epidermal growth factor (EGF), but is not detectably phosphorylated following stimulation with IL-2, IL-12, or erythropoietin. Human STAT6 gene is mapped to chromosome 12q13. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S7972-42M
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Leonard, WJ. et al. Annu. Rev. Immunol. 16:293-322 (1998). 2. Schindler, C. et al. Annu. Rev. Biochem. 64:621-651 (1995). 3. Quelle, FW. et al. Mol. Cell. Biol. 15:3336-3343 (1995).
Additional info: Recognizes human STAT6, phosphorylated at threonine 645.

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