Stearoyl CoA Desaturase 1 (SCD1)

Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis. The SCD1 gene is tightly regulated by signals such as insulin, leptin, carbohydrate, fatty acids and temperature. The enzyme (mouse 355 aa, rat 358 aa; ?37,000 Da) is constitutively expressed in adipose tissue and is induced in liver in response to fat-free, high-carbohydrate diet. The SCD-1 expression is higher in female than in male mice. The repression of RNA levels and enzyme activity of hepatic SCD-1 by leptin has been shown to significantly reduce the triglyceride storage, VLDL production and therefore an increase in fatty acid oxidation. Inhibition of SCD-1 may be beneficial for the treatment of obesity, hepatic steatosis and other metabolic disorders.\n\nApplications: \nSuitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S7900-05A

Size

100ug

Applications

ELISA, IHC, IP, WB

Hosts

Mouse

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.

P Type

Mab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG2b

References

1. Zhang Y, et al. Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule. Am. J. Physiol. Renal. Physiol. May 2006; 290(5): F1065-1073. 2. Gutierrez-Juarez R, et al. Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J. Clin. Invest. Jun 2006; 116(6): 1686-1695.

Additional Info

Recognizes human Stearoyl CoA Desaturase 1. Species crossreactivity: mouse