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Steffimycin B (Antibiotic U 40615)

Steffimycin B (Antibiotic U 40615)

Cat no: S7972-84

Supplier: United States Biological
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Steffimycin B is a anthracycline metabolite isolated from a Streptomyces sp. displaying antibacterial and antineoplastic properties. Binding to DNA, crystallographic studies suggest that it has a higher CpG base sequence specificity over the TpA step, similar to that of daunorubicin and nogalamycin. A close analogue was shown to be active against ras oncogene-expressed cells. Purity: >99% by HPLC Solubility: Soluble in ethanol, methanol, DMF or DMSO.
Catalogue number: S7972-84
Size: 1mg
Purity: >99% by HPLC
Alternative names: Antibiotic U 40615
References: 1. Molecular structure of antitumor drug steffimycin and modeling of its binding to DNA. Sriram M. et al. J. Biomol. Struct. Dyn. 1991, 9, 251. 2. Screening of antibiotics preferentially active against ras oncogene-expressed cells. Suzukake-Tsuchiya K. et al. J. Antibiot. 1990, 43, 1489. 3. Steffimycin B, a DNA binding agent. Reusser F. Biochim. Biophys. Acta 1975, 383, 266.

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