STK4, Active, Recombinant, Human, GST-Tag (MST1, Serine/Threonine-protein Kinase 4, Mammalian STE20-like Protein Kinase 1, MST-1, STE20-like Kinase MST1, Serine/Threonine-protein Kinase Krs-2, KRS2)

MST1 is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it is possible that this protein induces the chromatin condensation observed in this process.\n\nSource:\nRecombinant corresponding to aa2-488 from human STK4, fused to GST-tag at N-terminal, expressed in Sf9 cells via a baculovirus expression system.\n\nMolecular Weight:\n~81.5kD\n\nApplications:\nSuitable for use in the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nSpecific Activity:\n~73pmol/min/ug\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and store at -70 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

137378

Size

10ug

Form

Supplied as a liquid in 45mM Tris-HCl, pH 8.0, 124mM sodium chloride, 2.4mM potassium chloride, 3mM DTT, 18mM glutathione, 10% glycerol.

Purity

Purified (~50%)

References

1. Ura, S., et al. (2001). Proc. Natl. Acad. Sci. USA. 98(18):10148-53. 2. Taylor, L.K., et al. (1996). Proc. Natl. Acad. Sci. USA. 93(19):10099-104. 3. Song, H., et al. (2010). Proc. Natl. Acad. Sci. USA. 107(4):1431-6.