Stromal Cell Derived Factor 1beta, aa1-72, Recombinant, Mouse (SDF1b, CXCL12b, Pre-B Cell Growth-stimulating Factor, PBSF, hIRH, Chemokine (C-X-C Motif) Ligand 12b, TPAR1, SCYB12, TLSF-b)

Chemokine SDF-1 is highly conserved among species and belongs to a large family of small, structurally related cytokines. It is a chemoattractant for T lymphocytes, monocytes, and hemopoietic stem cells and is constitutively expressed in bone-marrow-derived stromal cells. Recent reports indicate that SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. SDF-1a and SDF-1b, are generated by alternative RNA splicing of transcripts encoded by a single gene. SDF-1a differs from SDF-1b by four C-terminal amino acid residues absent in SDF-1a. As yet, no functional differences have been reported.\n\nStromal Cell-Derived Factor-1beta (SDF1b) is a recently discovered protein belonging to the a-chemokine (C-X-C) family of cytokines. Murine SDF1b is an 8.5kD protein containing 72 amino acid residues.\n\nSource: E. coli\n\nForm: Lyophilized protein without additives.\n\nStability: Lyophilized SDF1b, though stable at room temperature, is best stored desiccated below 0 degrees C. Reconstituted human SDF1b should be stored in working aliquots at -20 degrees C.\n\nPurity: (same/more than) 98% by SDS-PAGE and HPLC analyses. \n\nEndotoxin: (same/less than) 0.1ng/ug\n\nReconstitution: Lyophilized SDF1b is soluble in water and most aqueous buffers. The lyophilized protein can be reconstituted in water to a concentration of 0.1-1mg/ml. It is recommended that further dilutions be made into buffer containing carrier protein or medium containing serum.\n\nBiological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 50-100ng/ml\n\nConcentration Range for most in vitro applications: 0.1-1mg/ml\n\nAA Sequence: KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRL KM \n\nCountry of Origin: USA

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