Stromal Interaction Molecule 1, CT (STIM1, GOK)

STIM1 is an essential and conserved component of store-operated Ca2+ channel function. It is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane (STIM1 translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium). STIM1 is a typical transmembrane protein with an extracellular N-terminal domain and a cytosolic C-terminal domain. The protein is highly hydrophobic with only a short region of hydrophobicity that likely represents the transmembrane region. The mouse STIM1 homologue (Stim1) was identified independently as a stromal-cell-derived gene product that binds to the surface of haematopoietic cells, particularly pre-B lymphoid cells, and can promote subsequent clonal expansion. Murine Stim1 is 96% identical with human STIM1 in aa sequence, and maps to a region of mouse chromosome 7 syntenic with human 11p15.5.\n\nApplications:\nSuitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1ug/ml\nImmunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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