Home  >  Products  >  STYX, Recombinant, Human, aa1-223, His-Tag (Serine/Threonine/Tyrosine-interacting Protein, Protein Tyrosine Phosphatase-like Protein)

STYX, Recombinant, Human, aa1-223, His-Tag (Serine/Threonine/Tyrosine-interacting Protein, Protein Tyrosine Phosphatase-like Protein)

Cat no: 045465


Supplier: United States Biological
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STYX, also known as serine/threonine/tyrosine-interacting protein, belongs to the protein-tyrosine phosphatase family. It contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase. The binding pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. It seems to play a role in spermiogenesis. Source: Recombinant corresponding to aa1-223 from human STYX, fused to His-tag at N-terminus, expressed in E.coli. Molecular Weight: ~28kD (247aa) confirmed by MALDI-TOF AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMEDVKL EFPSLPQCKE DAEEWTYPMR REMQEILPGL FLGPYSSAMK SKLPVLQKHG ITHIICIRQN IEANFIKPNF QQLFRYLVLD IADNPVENII RFFPMTKEFI DGSLQMGGKV LVHGNAGISR SAAFVIAYIM ETFGMKYRDA FAYVQERRFC INPNAGFVHQ LQEYEAIYLA KLTIQMMSPL QIERSLSVHS GTTGSLKRTH EEEDDFGTMQ VATAQNG Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: 045465
Size: 50ug
Form: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 1mM DTT, 0.1M sodium chloride, 30% glycerol.
Purity: ~85% (SDS-PAGE)
References: 1. Wishart MJ. et al. (1995) J. Biol. Chem. 270:26782-26785. 2. Wishart MJ. et al. (2002) Proc Natl Acad Sci USA 99:2112-2117.

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