SUCNR1 Polyclonal Antibody

Antigen: human SUCNR1 amino acids 100-150 . Host: rabbit . Cross Reactivity: (+) human, chimpanzee, new world monkey SUCNR1; predicted to react with dog, mouse, and rat SUCNR1 . Application(s): IHC and WB . SUCNR1 is a receptor for the citric acid cycle intermediate succinate that functions in establishing a neovascular network during development and in response to injury. It regulates the production of numerous angiogenic factors, including VEGF, and also is involved in the modulation of platelet function.

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SPECIFICATIONS

Catalog Number

10928

Applications

IHC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

portion of amino acids 100-150 of human SUCNR1

Storage Temp

-20

Shipping Temp

-20

Additional Info

SUCNR1 is a 334 amino acid-containing membrane receptor, belonging to the G-protein coupled receptor 1 family, characterized by an extracellular N terminus, seven transmembrane regions, and an intracellular C terminus and playing a role in cell communication. SUCNR1 is a receptor for the citric acid cycle intermediate succinate. It functions in establishing a neovascular network during development and in response to injury. SUCNR1, in response to increased succinate levels, regulates the production of numerous angiogenic factors, including VEGF, and also is involved in the modulation of platelet function. It is known to play an essential role in proliferative ischemic retinopathy and is an attractive target for treating diseases that stem from aberrant neovascularization in the mature retina such as diabetic retinopathy. Expression of SUCNR1 is common in kidney, liver, retina, platelets, and leukocytes.