Home  >  Products  >  Survivin (Apoptosis Inhibitor 4, Apoptosis Inhibitor-4, API4, Apoptosis Inhibitor Survivin, Baculoviral IAP Repeat-containing Protein 5, BIRC5, BIRC-5, EPR1, EPR-1, IAP4, SVV, TIAP)
Survivin (Apoptosis Inhibitor 4, Apoptosis Inhibitor-4, API4, Apoptosis Inhibitor Survivin, Baculoviral IAP Repeat-containing Protein 5, BIRC5, BIRC-5, EPR1, EPR-1, IAP4, SVV, TIAP)

Survivin (Apoptosis Inhibitor 4, Apoptosis Inhibitor-4, API4, Apoptosis Inhibitor Survivin, Baculoviral IAP Repeat-containing Protein 5, BIRC5, BIRC-5, EPR1, EPR-1, IAP4, SVV, TIAP)

Cat no: S8500-02P

Supplier: United States Biological
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Survivin is a 142aa protein belonging to the IAP family and containing one BIR repeat that is necessary for HBXIP binding. It is a component of the chromosomal passenger complex (CPC) that acts as a key regulator of mitosis by ensuring correct chromosome alignment and segregation, chromatin-induced microtubule stabilization and spindle assembly as well as mediates targeting of the chromosomal passenger complex to the centromere and midbody. It is a potentially significant protein in the diagnosis, prognosis and treatment of various cancers. Survivin is a critical regulator of multiple processes, including proliferation, apoptosis, and angiogenesis. Its isoforms play vital role in mitosis. Expression is seen in fetal kidney, liver, adenocarcinoma (lung, pancreas, colon, breast, uterus and prostate), high-grade lymphomas and various renal cell carcinoma cell lines. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Jurkat cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S8500-02P
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Hinnis, AR. et al. Br. J. Cancer. 96:639-645 (2007). 2. Liguang, Z. et al. Exp. Oncol. 29:121-125 (2007). 3. Weikert, S. et al. Fertil. Steril. 1:1100-1105(2005).
Additional info: Recognizes human Survivin. Species sequence homology: canine, monkey, porcine.

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