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Synaptophysin (CT) (Major synaptic vesicle protein p38)

Synaptophysin (CT) (Major synaptic vesicle protein p38)

Cat no: S9108-03A2

Supplier: United States Biological
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Synaptophysin is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38kDa (1). It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. It acts as a marker for the presynaptic vesicle, and functions in synaptic vesicle exocytois, including cholesterol-dependent vesicle biogeneis, regulation of SNARE assembly via interaction with VAMP/synaptobrevin, formation of the fusion pore initiating neurotransmitter release, and activation of vesicle endocytosis (2, 3). This gene has also been implicated in X linked mental retardation (4). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot:1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S9108-03A2
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH7.4, 50% glycerol and 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Johnston P.A., et al. (1989) J Biol Chem. 264:1268-1273. 2. Thiele C., et al. (2000) Nat Cell Biol. 2:42-49 3. Valtorta F., et al. (2004) Bioessays 26:445-453. 4. Tarpey P.S., et al. (2009) Nat Genet. 41(5):535-543.
Additional info: Recognizes Immunoprecipitate of human brain.

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