Synaptophysin (MRXSYP, Major synaptic vesicle protein p38)

Synaptophysin (SYP) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells. Ozcelik et al. (1990) concluded that the gene has 7 exons distributed over about 20 kb. SYP mapped the SYP locus to Xp11.23-p11.22. Regionalization of the gene on the X chromosome was also done with hamster/human hybrid cells in which various portions of the human X chromosome were present.\n\nUniProt Number:\nHuman(P08247), Mouse(Q62277), Rat(P07825)\n\nGene ID:\nSYP\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry (Paraffin and Frozen).\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Handling:\nStore at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term.\nAvoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

145243

Size

100ug

Applications

IHC, WB

Hosts

Mouse

Reactivities

Hum, Rat

Form

Ascites, supplied as a lyophilized powder. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

P Type

Mab

Isotype

IgG1

References

1. McMahon, H. T.; Bolshakov, V. Y.; Janz, R.; Hammer, R. E.; Siegelbaum, S. A.; Sudhof, T. C. : Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release. Proc. Nat. Acad. Sci. 93: 4760-4764, 1996.\n2. Cremin, S. M.; Greer, W. L.; Bodok-Nutzati, R.; Schwartz, M.; Peacocke, M.; Siminovitch, K. A. : Linkage of Wiskott-Aldrich syndrome with three marker loci, DXS426, SYP and TFE3, which map to the Xp11.3-p11.22 region. Hum. Genet. 92: 250-253, 1993.\n3. Ozcelik, T.; Lafreniere, R. G.; Archer, B. T., III; Johnston, P. A.; Willard, H. F.; Francke, U.; Sudhof, T. C. : Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse. Am. J. Hum. Genet. 47: 551-561, 1990.

Additional Info

Recognizes human and rat Synaptophysin. No crossreactivity with other proteins.