Synaptophysin (SYP, SYPH, SypI, Major Synaptic Vesicle Protein P38, Syn p38) (BIotin)

Synaptophysin labels normal neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas, gastrointestinal mucosa, Paneth

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SPECIFICATIONS

Catalog Number

S9108-09D

Size

250ul

Applications

FC, IHC

Hosts

Mouse

Reactivities

Hum, Mouse, Rat, Bov

Conjugates

Biotin

Form

Supplied as a liquid in PBS, pH 7.4.

P Type

Mab

Purity

Purified IgG

Isotype

IgG1

References

Gould, V.E., Wiedenmann, B., Lee, I., Schwechheimer, K., Dockhorn-Dworniczak, B., Radosevich, J.A., Moll, R. and Franke, W.W.: Synaptophysin expression in neuroendocrine neoplasms as determined by immunocytochemistry. Am. J. Pathol. 126, 243-257 (1987)\nGould, V.E., Lee, I., Wiedenmann, B., Moll, R., Chejfec, G. and Franke, W.W.: Synaptophysin: A novel marker for neurons, certain neuroendocrine cells and their neoplasms. Human Pathol. 17, 979-983 (1986)\nGould, V.E.: Synaptophysin - A new and promising Pan-neuroendocrine marker. Arch Pathol Lab Med 111, 791-794, (1987)\nKelly, R.B., Buckley, K.M., Burgess, T.L., Carlson, S.S., Caroni, P., Hooper, J.E., Katzen, A., Moore, H.-P., Pfeffer, S.R. and Schroer, T.A.: Membrane traffic in neurons and peptide-secreting cells. Cold Spring Harbor Symp. Quant. Biol. 48, 697-705 (1983)\nWiedenmann, B., Franke, W.W., Kuhn, C., Moll, R. and Gould, V.E.: Synaptophysin: A marker protein for euroendocrine cells and neoplasms. Proc. Natl. Acad. Sci. USA 83, 3500-3504 (1986)\nWiedenmann, B. and Franke, W.W.: Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell 45, 1017-1028 (1985)

Additional Info

Represents an excellent marker for several neuroendocrine, neuronal and adrenal tumors. Neuronal and adrenal tumors such as pheochromocytomas, paragangliomas, neuroblastomas, ganglioneuroblastomas. Neuroendocrine tumors of epithelial origin: Pancreatic islet cell carcinoma, bronchial and gastrointestinal carcinoids, medullary carcinoma of thyroid. Polypeptide reacting: Mr 38,000 transmembrane glycoprotein of presynaptic vesicles. Reactivities on Cultured Cell Lines (tested so far): Rat PC-12 cell line. Species Crossreactivity: Human, bovine, rat, mouse.