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Synip (Syntaxin 4-Interacting protein)

Cat no: S9115-26

Synip (Syntaxin 4-Interacting protein)

Insulin binds to and activates its receptor and initiates a signaling cascade that eventually induces the translocation of the Glut4 glucose transporter from its intracellular locations to the plasma membrane. Initiating this pathway facilitates glucose uptake in fat and skeletal muscle cells (1). Synip and Syntaxin 4 are two proteins thought to be involved in the recruitment of Glut4-containing vesicles to plasma membrane (2,3). Synip associates with Syntaxin 4 when insulin is absent. Insulin signaling triggers the dissociation of the two proteins and allows Syntaxin 4 to complex with VAMP2, which is essential for Glut4 translocation to plasma membrane (2

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SPECIFICATIONS

Catalog Number

S9115-26

Size

100ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol and less than 0.02% sodium azide.

P Type

Mab

Purity

Supernatant

Isotype

IgG

References

(1) Watson, R.T. and Pessin, J.E. (2006) Trends Biochem. Sci. 31, 215

Additional Info

Detects endogenous levels of total Synip protein.

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