Synphilin 1 (Synphilin-1, SYPH1, Alpha Synuclein-interacting Protein, MGC39814, Synuclein alpha Interacting Protein (Synphilin), SNCAIP)

Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shares a high level of identity with its human counterpart, particularly in regions containing ankyrin-like motifs and the coiled-coil domain. Expression pattern of synphilin-1 in tissues is similar in both mouse and human. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and also Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1.\n\nApplications: \nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S9116-01A

Size

100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Rat

Form

Supplied as a lyophilized powder. Reconstitute in 100ul of sterile water. Centrifuge to remove any insoluble material.

P Type

Pab

Purity

Serum

References

1. Kruger,R. Cell Tissue Res. 318 (1), 195-199 (2004) ; 2. Lee,G., etal. J. Biol. Chem. 279 (8), 6834-6839 (2004) ; 3. Tanaka,M., et al. J. Biol. Chem. 279 (6), 4625-4631 (2004) ; 4. Nagano,Y., et al. J. Biol. Chem. 278 (51), 51504-51514 (2003) ; 5. Marx,F.P., etal. Hum. Mol. Genet. 12 (11), 1223-1231 (2003) ; 6. Junn,E., et al. J. Biol. Chem. 277 (49), 47870-47877 (2002) ; 7. Chung,K.K., et al. Nat. Med. 7 (10), 1144-1150 (2001) ; 8. Kawamata,H., et al. J. Neurochem. 77 (3), 929-934 (2001) ; 9. Engelender,S., et al. Nat. Genet. 22 (1), 110-114 (1999)

Additional Info

A high level of specificity has been shown for this antiserum by IHC on human brain. Species Crossreactivity: This antiserum is known to react with rat and human synphilin-1a.