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SYT4, Recombinant, Human, aa38-425, His-Tag (Synaptotagmin-4, HsT1192, KIAA1342)

Cat no: 137223

SYT4, Recombinant, Human, aa38-425, His-Tag (Synaptotagmin-4, HsT1192, KIAA1342)

Synaptotagmin-4, also known as SYT4, belongs to the synaptotagmin family proteins. Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. SYT4 is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus. The proximity of the SYT4 gene to markers of several psychiatric disorders suggest an involvement of SYT4 in human disease.\n\nSource: \nRecombinant protein corresponding to human SYT4, fused to His-tag at N-terminal expressed in E.coli.\n\nMolecular Weight: \n~46.1kD (409aa) (MALDI-TOF)\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MCQRKSSKSN KTPPYKFVHV LKGVDIYPEN LNSKKKFGAD DKNEVKNKPA VPKNSLHLDL EKRDLNGNFP KTNLKPGSPS DLENATPKLF LEGEKESVSP ESLKSSTSLT SEEKQEKLGT LFFSLEYNFE RKAFVVNIKE ARGLPAMDEQ SMTSDPYIKM TILPEKKHKV KTRVLRKTLD PAFDETFTFY GIPYTQIQEL ALHFTILSFD RFSRDDIIGE VLIPLSGIEL SEGKMLMNRE IIKRNVRKSS GRGELLISLC YQSTTNTLTV VVLKARHLPK SDVSGLSDPY VKVNLYHAKK RISKKKTHVK KCTPNAVFNE LFVFDIPCEG LEDISVEFLV LDSERGSRNE VIGQLVLGAA AEGTGGEHWK EICDYPRRQI AKWHVLCDG\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

137223

Size

20ug

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 0.1M NaCl, 20% glycerol, 1mM DTT.

Purity

~90% (SDS-PAGE)

References

1. Ferguson G D., et al. (2000) J Biol Chem. 275:36920-36926. 2. Ibata K., et al. (2002) Neurosci Res. 43:401-406.

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