Tau (Neurofibrillary Tangles Marker, Microtubule-associated Protein, MAP, Paired helical filament-tau, PHF-tau)

Tau proteins are important in the assembly of microtubules. In normal brain, Tau is localized within the axons of the neurons, but in some neuropathological lesions it accumulates within the body of the neuron. Tau proteins are thought to be abnormally phosphorylated in certain disease states. Tau has been immunohistochemically localized to neurofibrillary tangles of Alzheimer

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SPECIFICATIONS

Catalog Number

T1029

Size

50ug

Applications

ELISA, IHC, IP, WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat, Bov, Sheep

Form

Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.

P Type

Mab

Purity

Purified by Protein A/G affinity chromatography.

Isotype

IgG1

References

US Biological application references: 1. Rouzier, R. et al., (2005) PNAS 102:8315-8320. 2. Shao, Y.-Y., et al., (2010) Japanese J. of Clinical Oncology 40:286-293. 3. Bamias, A. et al., (2010) Cancer Chemotherapy and Pharmacology 65:1009-1021. 4. Bordeaux, J. et al., (2010) BioTechniques 48:197-209. 5. Baquero, M.T. et al., (2012) Cancer, DOI: 10.1002/cncr.27453. 1. Papasozomenos, S.C. & Shanavas, A., (2002) PNAS USA 99:1140-1145. 2. Rapoport, M., et al., (2002) PNAS USA 99:6364-6369. 3. Takahashi, S., et al., (2003) J. Biol. Chem. 278:10,506-10,515.

Additional Info

Recognizes and is highly specific for non-phosphorylated and phosphorylated forms of bovine Tau proteins (45-68kD). Does not crossreact with other microtubule associated proteins (MAPs) or tubulin. The epitope is located in the middle region of Tau. \nSpecies Crossreactivity: human, sheep, mouse and rat.