Tau (Tau Protein, Microtubule-associated protein tau, MAPT) (Biotin)

Supplier:

United States Biological

Cat no: T1033

Tau (Tau Protein, Microtubule-associated protein tau, MAPT) (Biotin)

Tau is a heterogeneous group of proteins that range in molecular weight from 50-67kD. They are instumental in the assembly of microtubules and have been associated with some disease states. In normal brain, tau is localized in the axons of the neurons but in some neuropathological lesions, it accumulates within the body of the neuron. Tau protein is a microtubule-associated protein predominantly localized to neuronal axons. Tau promotes tubulin polymerization and the stabilization of microtubules. Hyperphosphorylated forms of Tau are the major components of paired helical filaments (PHF) found in the neurofibrillary tangles which characterize Alzheimer

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SPECIFICATIONS

Catalog Number

T1033

Size

250ug

Applications

IHC

Hosts

Mouse

Reactivities

Hum, Bov, Ch/Bird, NHP

Conjugates

Biotin

Form

Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, 2mM EDTA, 1.0% BSA. Labeled with biotin.

P Type

Mab

Purity

Purified

Isotype

IgG1

References

1. Binder. L.I. et al (1985) J. Cell Biol. 101:1371. 2. Papasozomenos, S.C. et al (1987) Cell Motility and the Cytoskeleton 8:210. 3. Lewis, S.A. et al (1989) Nature 342:498.

Additional Info

Recognizes an epitope of the (Mr 52-68kD) microtubule associated protein tau in bovine brain. Reacts with tau in the phosphorylated and non-phosphorylated forms in human, bovine monkey and chicken.

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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