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Tfr-2, ID (Tfr2 Protein, zgc:123043)

Tfr-2, ID (Tfr2 Protein, zgc:123043)

Cat no: T8199-49

Supplier: United States Biological
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Transferrin, a serum protein with 2 iron binding sites, is the major carrier of ferric iron in human plasma and is required to deliver iron to developing erythroid and other cells. Iron-bound holotransferrin binds transferrin receptor 1 (TfR1) on the surface of the cell, resulting in endocytosis of an endosome containing both transferrin and TfR1. After acidification of the endosome, ferrous iron exits the endosome via the divalent metal transporter (DMT1). Transferrin receptor 2 (TfR2), a homolog of TfR1, with restricted expression to hepatocytes and erythroid cells, binds transferrin at lower affinity than TfR1 and is involved in the regulation of iron homeostasis. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Optimal dilutions to be determined by the researcher. Control Peptide: T8199-49P Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8199-49
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Aisen P. Int J Biochem Cell Biol. 2004;36:2137-2143. 2. Fleming MD, et al. Proc Natl Acad Sci U S A. 1998;95:1148-1153. 3. Garrick MD, et al. J Biol Chem. 1993;268:14867
Additional info: Recognizes zebrafish TfR-2.

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