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TGIF2 (Homeobox Protein TGIF2, 5'-TG-3'-interacting Factor 2, TGF-beta-induced Transcription Factor 2, TGFB-induced Factor 2)

TGIF2 (Homeobox Protein TGIF2, 5'-TG-3'-interacting Factor 2, TGF-beta-induced Transcription Factor 2, TGFB-induced Factor 2)

Cat no: T3630-11C

Supplier: United States Biological
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Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:16,000 Western Blot: 0.3-1ug/ml, observed in lysates of A431, A549 and HEK293 cell lines on ~22kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T3630-11C
Reactivities: Human, Mouse, Rat, Canine, Porcine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Melhuish TA, Gallo CM, Wotton D. TGIF2 interacts with histone deacetylase 1 and represses transcription. J Biol Chem. 2001 Aug 24;276(34):32109-14. Epub 2001 Jun 26.
Additional info: Recognizes human TGIF2. Species sequence homology: Canine, mouse, porcine and rat.

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