Thromboxane B2 Express EIA Kit - Monoclonal

Thromboxane A2 (TXA2), produced from arachidonic acid, causes irreversible platelet aggregation and contraction of vascular and bronchial smooth muscle. TXA2 is rapidly hydrolyzed non-enzymatically to TXB2, which is then quickly metabolized to urinary metabolites for clearance by the kidneys. Urinary analysis of TXB2 accurately reflects intrarenal TXA2 synthesis, while measurement of 11-dehydro and 2,3-dinor thromboxane metabolites gives the best estimate of systemic TXA2 secretion. Cayman's Thromboxane B2 (TXB2) Express EIA is a competitive assay that provides a rapid, accurate measurement of TXB2 from plasma, urine, and cell culture supernatants. The assay typically exhibits an IC50 value (50% B/B0) of approximately 176 pg/ml and a detection limit (80% B/B0) of approximately 45 pg/ml.

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SPECIFICATIONS

Catalog Number

10004023

Form

96 Well

P Type

Assay Kits|Thromboxanes|Eicosanoids

Weight

0

Storage Temp

-20

Shipping Temp

-20

Additional Info

Thromboxane A2 (TXA2) is produced from arachidonic acid by many cells and causes irreversible platelet aggregation and contraction of vascular and bronchial smooth muscle. TXA2 is rapidly hydrolyzed non-enzymatically to TXB2, which is then quickly metabolized to urinary metabolites for clearance by the kidneys. Urinary analysis of TXB2 accurately reflects intrarenal TXA2 synthesis, while measurement of 11-dehydro and 2,3-dinor thromboxane metabolites gives the best estimate of systemic TXA2 secretion. Cayman's Thromboxane B2 (TXB2) Express EIA is a competitive assay that provides accurate measurements of TXB2 from a variety of sample types. As the name implies, this kit was designed for rapid measurements of TXB2. Features of the kit include: Fast - two hour incubation; 1 hour development . Standard curve range: 15.6 - 2,000 pg/ml . Patented AChE Tracer technology . Applicable to TXB2 measurements in plasma, urine, and cell culture.