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Thymic Stromal Lymphopoietin (TSLP)

Thymic Stromal Lymphopoietin (TSLP)

Cat no: T9127-03A

Supplier: United States Biological
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TSLP is a 132aa secreted haemopoietic cytokine which shares biological properties with interleukin-7 (IL-7), including involvement in B-cell development, and the activation and phosphorylation of STAT3 and STAT5. TSLP is expressed in the heart, liver and prostate and functions through binding to a receptor complex consisting of the TSLPR (thymic stromal lymphopoietin receptor) and the IL-7R alpha chain. Properties attributed to TSLP include the induction of monocytes to release T cell-attracting chemokines, enhancing the maturation of CD11c(+) dendritic cells and their ability to stimulate T cells, and strong evidence suggests that TSLP plays a pivotal role in allergic immune responses. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 0.5-2ug/ml Western Blot: 0.1-0.2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: T9127-03A
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a lyophilized powder from PBS, pH 7.2. No preservative added. Reconstitute with 100ul sterile ddH2O.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Liu, Y-J. et al. (2007) TSLP: An epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu. Rev. Immunol. 25: 193-219.
Additional info: Recognizes human TSLP.

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