Home  >  Products  >  TIM-4 (T-cell Immunoglobulin and Mucin Domain-containing Protein 4, TIMD-4, Spleen, Mucin-containing, Knockout of Lymphotoxin Protein, SMUCKLER, T-cell Membrane Protein 4, Timd4, Tim4)
TIM-4 (T-cell Immunoglobulin and Mucin Domain-containing Protein 4, TIMD-4, Spleen, Mucin-containing, Knockout of Lymphotoxin Protein, SMUCKLER, T-cell Membrane Protein 4, Timd4, Tim4)

TIM-4 (T-cell Immunoglobulin and Mucin Domain-containing Protein 4, TIMD-4, Spleen, Mucin-containing, Knockout of Lymphotoxin Protein, SMUCKLER, T-cell Membrane Protein 4, Timd4, Tim4)

Cat no: T5469-94

Supplier: United States Biological
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TIMD-4 is a type I transmembrane protein belonging to the immunoglobulin superfamily, containing one Ig-like V-type (immunoglobulin-like) domain. TIMD-4 is expressed in Mac1+ cells in spleen, lymph nodes and fetal liver. TIMD-4 binds apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. TIMD-4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIMD-4 is involved in regulating T-cell proliferation and lymphotoxin signaling. TIMD-4 and TIMD-1 are phosphatidylserine receptors for the engulfment of apoptotic cells, and are also involved in intracellular signaling in which exosomes are involved. This monoclonal antibody blocks the engulfment of apoptotic cells by thymic macrophages. Applications: Suitable for use in Flow Cytometry, ELISA, Functional Studies and Immunofluorescence. Not suitable for use in Immunohistochemistry or Western Blot. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T5469-94
Reactivities: Mouse
Applications: ELISA, Flow Cytometry, Immunofluorescence
Size: 100ug
Form: Supplied as a liquid in PBS, 0.1% BSA.
P type: Mab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Miyanishi, M et al; Identification of Tim4 as a phosphatidylserine receptor. Nature 2007, 450: 435.
Additional info: Recognizes mouse TIM-4.

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