Tipifarnib

Cat no: 021888

Supplier: United States Biological

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A farnesyltransferase inhibitor. Sensitizes human multiple myeloma cell to proteasome inhibition by blocking degradation of bortezomib-induced aggresomes. Also shown to inhibit the growth of myeloid leukemia cell lines and primary leukemia cells by inducing apoptosis and cell-cycle blockage when combined with rapamycin(R124000). Melting Point: 211-213 degrees C (dec.) Solubility: Chloroform, Methanol Specific Rotation: +20.9 degrees C (c=0.7, Methanol) Method for Determining Identity: Proton NMR, (CDCI3) Spectroscopic and Mass Spectrometric Analysis TLC Conditions: SiO2; Dichloromethane: Methanol=9:1; Visualized with UV and AMCS; Single spot. Rf=0.45. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards:

Catalogue number:	021888
Size:	2.5mg
Form:	Supplied as an off-white to pale beige solid.
Purity:	90%
Alternative names:	6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; (R)-(+)-R 115777; Zarnestra;
References:	David, E., et al.: Blood, 116, 5285 (2010); Nagai, T., et al.: Leukemia Res., 34, 1057 (2010); Hong, D., et al.: Clin. Cancer Res., 15, 7061 (2009)

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Tipifarnib

Cat no: 021888

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