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Tipifarnib

Cat no: 021888

Tipifarnib

A farnesyltransferase inhibitor. Sensitizes human multiple myeloma cell to proteasome inhibition by blocking degradation of bortezomib-induced aggresomes. Also shown to inhibit the growth of myeloid leukemia cell lines and primary leukemia cells by inducing apoptosis and cell-cycle blockage when combined with rapamycin(R124000).\n\nMelting Point:\n211-213 degrees C (dec.) \n\nSolubility:\nChloroform, Methanol \n\nSpecific Rotation:\n+20.9 degrees C (c=0.7, Methanol)\n\nMethod for Determining Identity:\nProton NMR, (CDCI3) Spectroscopic and Mass Spectrometric Analysis \n\nTLC Conditions:\nSiO2; Dichloromethane: Methanol=9:1; Visualized with UV and AMCS; Single spot. Rf=0.45.\n\nImportant Note: \nThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. \n\nToxicity and Hazards:

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SPECIFICATIONS

Catalog Number

021888

Size

2.5mg

Form

Supplied as an off-white to pale beige solid.

Purity

90%

References

David, E., et al.: Blood, 116, 5285 (2010); Nagai, T., et al.: Leukemia Res., 34, 1057 (2010); Hong, D., et al.: Clin. Cancer Res., 15, 7061 (2009)

Alternative Names

6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; (R)-(+)-R 115777; Zarnestra;

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