TL1A (TNFSF15, Tumor Necrosis Factor Ligand Superfamily Member 15)

Members in the TNF and its receptor superfamilies regulate immune responses and induce apoptosis. DR3 (also termed Wsl-1, Apo-3, TRAMP, and LARD) (1-5) is preferentially expressed by T lymphocytes and upregulated during T cell activation. The ligand for DR3 was recently identified and designated TL1A (6). TL1A also binds decoy receptor DcR3/TR6 (7,8), which is expressed in several lung and colon carcinomas and in some normal tissues. TL1A induces apoptosis and NF-kB activation in DR3 expressing cells, which is antagonized by DcR3. TL1A is upregulated by proinflammatory cytokines TNF and IL-1. TL1A is a longer variant of TL1 (also called VEGI).\n\nApplications: \nCan be used for detection of TL1A by Western blot at 0.5 to 1ug/ml.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20 degrees C or colder. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

T8038-05

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.

P Type

Pab

Purity

Purified by Ion Exchange chromatography.

Isotype

IgG

References

1. Chinnayan AM, et al. Science 1996; 274:990-2. 2. Kitson J, et al. Nature 1996; 384:372-5. 3. Screaton GR, et al. Proc. Natl. Acad. Sci. USA 1997; 94:4615-9. 4. Bodmer JL,et al Immunity 1997; 6:79-88. 5. Marsters SA, et al. Curr. Biol. 1996; 6:1669-76. 6. Migone TS, et al Immunity 2002; 16:479-92. 7. Pitti RM, et al Nature 1998; 396:699-703. 8. Yu KY,et al J. Biol. Chem. 1999; 274:13733-6.

Additional Info

Recognizes human TL1A. It will not crossreact with TL1. Species Crossreactivity: Mouse and rat.